<i>PTPRD</i> mutations are common in HNSCC and other cancers.

<p>(A) Localization of PTPRD protein mutations reported in HNSCC tumors. Red: TCGA tumors [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0135750#pone.0135750.ref009" target="_blank">9</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0135750#pone.0135750.ref010" target="_blank">10</a>]; Green: from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0135750#pone.0135750.ref006" target="_blank">6</a>]; Blue: from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0135750#pone.0135750.ref007" target="_blank">7</a>]. IG, Immunoglobulin; IG2, Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; FN3, Fibronectin type 3 domain; PTPc, Protein tyrosine phosphatase, catalytic domain. (B) Frequency of <i>PTPRD</i> mutations in human cancers as determined by TCGA, with HNSCC shown in red.