Hierarchical clustering of bacterial genes expressed in C3HeB/FeJ mouse lungs.

<p>A snapshot of few bacterial genes induced in C3HeB/FeJ mouse lungs upon infection with <i>Mtb</i> or <i>Mtb</i>:Δ<i>dosR</i> or <i>Mtb</i>:Δ<i>dosS</i> or <i>Mtb</i>:Δ<i>dosT</i> and their comparison with genes expressed during NRP [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0135208#pone.0135208.ref024" target="_blank">24</a>] is shown. A gradual decrease or increase in color intensity indicates low (blue) or high (orange) expression. For example, a gradual increase in gene expression over 80 days of hypoxia indicates their requirement during both hypoxia <i>in-vitro</i> and chronic phase of infection in C3HeB/FeJ mouse lungs.