HCV sensitivity to exogenous IFN-I and RBV in H77S.3 Infection System.

<p>(A) IFN-I dose dependent control of HCV replication in the human hepatoma Huh7.5 cell line. HCV RNA-transfected Huh7.5 were grown to achieve stable replication and then cultured with different doses of recombinant IFN-I over 3 days. HCV replication was monitored by measurement of luciferase activity. (B) RBV effect on HCV replication in the H77S.3 Infection System. HCV RNA-transfected cells were grown in the presence of RBV and with the combination of low dose IFN-I (10u) and RBV. The viral replication was monitored as described above. The values are shown as mean with SD. One-way analysis of variance (ANOVA), followed by Bonferroni’s multiple-comparison test was used to compare between HCV and treatment groups and within the relevant groups as indicated in the figures. *p≤0.05, **p≤0.01,***p≤0.001.