Osteopontin Deficiency Accelerates Spontaneous Colitis in Mice with Disrupted Gut Microbiota and Macrophage Phagocytic Activity - Fig 2

<p>(<b>A</b>) Enhanced <i>OPN</i> mRNA synthesis in the colonic tissues of IL-10 KO mice. Representative images of FISH for <i>OPN</i> mRNA in the rectal tissues from WT, IL-10 KO, and OPN/IL-10 DKO mice at 4 weeks of age. Scale bar = 100 μm. (<b>B</b>) Enhanced <i>OPN</i> expression localized to the colonic epithelial cells. Representative images of FISH for <i>OPN</i> mRNA (red) and immunofluorescent staining for E-cadherin (green) in the rectal tissues from IL-10 KO mice at 4 weeks of age. Scale bar = 100 μm.