Level of NZB mtDNA across generations in a heteroplasmic mouse lineage produced by cytoplasmic transfer.
- Thiago Simões Machado (783911)
- Carolina Habermann Macabelli (544023)
- Juliano Rodrigues Sangalli (544032)
- Thiago Bittencourt Rodrigues (783912)
- Lawrence Charles Smith (544033)
- Flávio Vieira Meirelles (416015)
- Marcos Roberto Chiaratti (544035)
Publication date
August 2015
DOIAbstract
<p>Circles depict the level of NZB mtDNA in mice estimated by ARMS-qPCR from ear biopsies. Filled circles depict females that were backcrossed (BC) with B6 males to obtain the next generation progeny (BC<sub>1</sub>, BC<sub>2</sub>, BC<sub>3</sub>, BC<sub>4</sub> and BC<sub>5</sub>). The level of NZB mtDNA was not determined for males, except in the founder lineage where males are depicted by empty circles. In the remaining generations (BC<sub>1</sub>, BC<sub>2</sub>, BC<sub>3</sub>, BC<sub>4</sub> and BC<sub>5</sub>) empty circles depict females that were not mated. Bars represent the means.</p
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