Reversible segregation of microtubules and neurofilaments in a single realization of the model.

<p>Neurofilament transport is blocked starting at <i>t</i> = 1 h and restored at <i>t</i> = 13 h. (A-F) Snapshots of the positions of microtubules, neurofilaments and organelles at <i>t</i> = 1 h, 3 h, 6 h, 12 h, 14 h, 20 h. All panels are from a single realization of the model. Large black dots are microtubules; small grey dots are free neurofilaments; small purple dots are neurofilaments engaged with microtubules; large cyan circles are organelles. (A) Microtubules and neurofilaments form a mixture under normal conditions. (B-D) Blockage of neurofilament transport leads to gradual segregation of microtubules and neurofilaments. (E,F) Restoration of neurofilament transport causes remixing of microtubules and neurofilaments. Parameters used: <i>n</i>^<i>M</i> = 56, <i>n</i>^<i>N</i> = 361. Neurofilament on-rate </p><p></p><p></p><p></p><p><mi>k</mi></p><p><mi>o</mi><mi>n</mi></p><mi>N</mi><p></p><p></p><p></p><p></p> equals 0 between <i>t</i> = 1 h and 13 h. All other parameters are the same as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004406#pcbi.1004406.t001" target="_blank">Table 1</a>.<p>