Iron deficiency results in attenuated immune-mediated hepatitis following ConA administration.

<p>(A) Serum levels of alanine aminotransferase (ALT; IU/mL) before, 6 hours and 12 hours after administration of ConA in mice fed for 3 weeks with an iron deficient (IrDef) or iron replete (IrRepl) diet. (B) Cytokine levels in serum samples collected before, 6 hours and 12 hours after the administration of ConA. (C) Transcript levels of <i>Il4</i>, <i>Il6 and TNFα</i> in liver tissue samples collected before and 12 hours after the administration of ConA. (D) Representative liver histology (200x) at 12 hours after the administration of ConA (upper panel) and histologic evaluation of necrosis and infiltration (lower panel).