Multivariable analysis of intermediate levels of sFRP3 as a predictor of outcome.

<p>sFRP3, 2^nd tertile <i>vs</i>. 1^st and 3^rd tertile, as predictor of outcome. All Hazard Ratios (HR) are given as HR (95% confidence interval). C index, Δ; difference in C index between fully adjusted model with and without inclusion of sFRP3, corresponding (<i>p</i>-value). Net Reclassification Improvement (NRI); calculated from C-indexes for fully adjusted models with and without inclusion of sFRP3, corresponding (<i>p</i>-value). Unadjusted (n = 1444). The models are adjusted as follows: Step 1 (n = 1441): Ejection fraction, New York Heart Association functional class, age, body mass index, diabetes mellitus, sex, intermittent claudication and heart rate. Step 2 (n = 1428): All variables from Step 1 as well as ApoB/Apo A-1 ratio and estimated glomerular filtration rate. Step 3 (1194): all variables from Step 2 as well as C-reactive protein and amino-terminal pro B-type natriuretic peptide. CV, cardiovascular; WHF, worsening heart failure.</p><p>Multivariable analysis of intermediate levels of sFRP3 as a predictor of outcome.