Additional file 3: of Harmful somatic amino acid substitutions affect key pathways in cancers

This file contains supplementary Figure S2. Distribution of predicted probabilities of harmfulness for cancer variants. a) Density plot of predicted probabilities of harmfulness for all AASs and most frequent AASs in COSMIC database. AASs present in more than 25 samples in COSMIC were referred as most frequent. The predicted probability ranges from 0–1 but the plots are extrapolated by default to 3 times the bandwidth from the extreme values. b) Density plot of predicted probabilities of harmfulness for somatic variation datasets obtained from ClinVar, DoCM and TP53 database. c) Venn diagram of overlap between somatic variations obtained from ClinVar, DoCM and TP53 database. d) Venn diagrams of overlap between frequent variations in COSMIC with somatic variations obtained from ClinVar, DoCM and TP53 database. (PDF 240 kb