Convergent evolution in capsid targeting among Old World monkey TRIM5αs.

<p>A. The indicated TRIM5αs were screened against a panel of HIV-1, SIVmac239 and SIVmac239 viruses with single amino acid substitutions on the CA surface. A key relating the mutation to the position in SIVmac CA and HIV-1 CA is found in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005085#ppat.1005085.t002" target="_blank">Table 2</a>. Extant TRIM5αs are separated by tribe (Papionini and Cercopithecini). Values above 100-fold are given as >100, reflecting the limitations of sensitivity of the FACS assay. Values for each data point can be found in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005085#ppat.1005085.s011" target="_blank">S2 Dataset</a>. B. A Venn diagram showing the overlap between mutations resulting in sensitivity to ancestral TRIM5α-V1:Q and cercopithecin and papionin TRIM5αs.