Congenic CAST-derived interval containing the <i>Mpkd1-2</i> loci and its effects on renal cystic disease progression.

<p>a) The CAST-derived segment of Chr 4 corresponding to <i>Mpkd1-2</i> interval is delimited by the marker, D4Mit80 (shaded area). The breakpoint between the proximal CAST/E-derived and distal B6-derived segment of Chr 4 occurred between markers D4Mit80 (37.7 cM) and D4Mit175 (45.7 cM). b) The predicted cystic disease-modulating effects of the CAST-derived <i>Mpkd1-2</i> loci was tested by comparing the renal cystic phenotypes in <i>Cys1</i>^{<i>cpk/cpk</i>} mutants that were heterozygotes for the CAST-derived (CAST/Ei; n = 9) <i>Mpkd1-2</i> interval to <i>Cys1</i>^{<i>cpk/cpk</i>} mutants from the same cross that were homozygous B6 for the <i>Mpkd1-2</i> interval (n = 14). The genetic background of both groups was B6. Diamonds represent values for individual animals. The line indicates the mean value for each group.