<p>X-axis: timepoint (n). Y-axis: random realizations of T cells in generation 1. The green lines represent the 1000 simulated sample paths. The red dashed line indicates the expected value predicted by the model and the blue dashed line represents the mean value of the sample paths obtained through stochastic simulations. The T cells in generation 1 simulations show the typical T cell clonal expansion and contraction profiles. (A) Draining Lymph node; (B)Migrating CD4+ T cell in the transfer compartment; (C) TR compartment; (D) Iliac lymph node compartment; (E) Spleen compartment; (F) Mesenteric lymph node compartment.</p
<p>The 30-year time evolution of the scaled level of -autoreactive T-cells: (A1–A4), -autoreactive ...
<div><p>The study of the initial phase of the adaptive immune response after first antigen encounter...
The study of the initial phase of the adaptive immune response after first antigen encounter provide...
<p>(a) Cells are initialized as a monolayer with four endothelial cells (red) representing cross-sec...
Each row represents the peak CD4+ T cell response in a Monte Carlo simulation, where 50 realizations...
<p><b>(A)</b> We consider circulation of Ag-specific T cells in mice between blood and T cell zones ...
<p>Throughout, dLN numbers refer to LNs represented by a single sphere. <b>(A)</b> Trajectories illu...
<p>The results of the stochastic simulation can be shown as phase plots of stem cells and transit am...
<p>Time evolution of: populations by cell type (top), local fitness by cell type (middle), and neigh...
<p>A. Individual T cell clone growth simulations accounting for peptide-HLA complex binding affinity...
T-cell primary activation is a key event in the initiation of the adaptive immune response. Quantify...
T-cell primary activation is a key event in the initiation of the adaptive immune response. Quantify...
T-cell primary activation is a key event in the initiation of the adaptive immune response. Quantify...
Adaptive immune responses are complex dynamic processes whereby B and T cells undergo division and d...
<p>(A) CD4+ T cell dynamics predicted by the two-compartment model. (B) Simulation of the model with...
<p>The 30-year time evolution of the scaled level of -autoreactive T-cells: (A1–A4), -autoreactive ...
<div><p>The study of the initial phase of the adaptive immune response after first antigen encounter...
The study of the initial phase of the adaptive immune response after first antigen encounter provide...
<p>(a) Cells are initialized as a monolayer with four endothelial cells (red) representing cross-sec...
Each row represents the peak CD4+ T cell response in a Monte Carlo simulation, where 50 realizations...
<p><b>(A)</b> We consider circulation of Ag-specific T cells in mice between blood and T cell zones ...
<p>Throughout, dLN numbers refer to LNs represented by a single sphere. <b>(A)</b> Trajectories illu...
<p>The results of the stochastic simulation can be shown as phase plots of stem cells and transit am...
<p>Time evolution of: populations by cell type (top), local fitness by cell type (middle), and neigh...
<p>A. Individual T cell clone growth simulations accounting for peptide-HLA complex binding affinity...
T-cell primary activation is a key event in the initiation of the adaptive immune response. Quantify...
T-cell primary activation is a key event in the initiation of the adaptive immune response. Quantify...
T-cell primary activation is a key event in the initiation of the adaptive immune response. Quantify...
Adaptive immune responses are complex dynamic processes whereby B and T cells undergo division and d...
<p>(A) CD4+ T cell dynamics predicted by the two-compartment model. (B) Simulation of the model with...
<p>The 30-year time evolution of the scaled level of -autoreactive T-cells: (A1–A4), -autoreactive ...
<div><p>The study of the initial phase of the adaptive immune response after first antigen encounter...
The study of the initial phase of the adaptive immune response after first antigen encounter provide...