Model for the conserved role of WWOX in TNFα-mediated apoptosis <i>in vivo</i> in <i>D</i>. <i>melanogaster</i>.

<p>The function of WWOX in promoting cell death in response to Egr/TNFα signalling (through Wengen/TNFR) is mediated by ROS and Caspase 3. This can be modulated though expression of SOD enzymes that act to limit cellular levels of ROS and is also responsive to the metabolic status of cells.