Effect of RTA 405 on doxorubicin- and cisplatin-mediated growth inhibition.

<p><b>A</b>-<b>B</b>. Effect of RTA 405 treatment on <i>NQO1</i> (left panel) and <i>GCLM</i> (right panel) mRNA levels in HCT 116 (A) and MDA-MB-231 (B) cells. Cells were treated with the indicated concentrations of RTA 405 for 2, 6, or 24 hours and mRNA levels were assessed by qPCR. Data points are the mean of three independent experiments. Error bars are SD. <b>C-D.</b> Effect of RTA 405 treatment on the growth inhibitory activity of doxorubicin (left panel) or cisplatin (right panel) in HCT 116 (C) and MDA-MB-231 (D) cells. Cells were treated with the indicated concentrations of RTA 405 for 24 hours and then treated with doxorubicin or cisplatin for an additional 72 hours. Cell viability was determined using the SRB assay. <i>Data points</i>, mean percent survival of triplicates; <i>error bars</i>, SD. Data is representative of three individual experiments.