Rescue of social behavior deficits in P<i>ten</i>^<i>+/-</i> mice by SB 242084 administration.

<p>Results of three-chamber social approach after administration of SB 242084 or vehicle to wild-type and <i>Pten</i>^<i>+/-</i> adult female mice. <b>(A)</b> Time spent in each chamber. For vehicle treated groups, n = 16 wild-type and 17 <i>Pten</i>^<i>+/-</i>; for SB 242084-treated groups, n = 15 wild-type and 16 <i>Pten</i>^<i>+/-</i>. *** p < 0.001 using paired-samples t-test <b>(B)</b> Approach-avoidance score. ** p < 0.01 using planned comparisons. <b>(C)</b> Preference index.