Functions of IP and TP receptors in HTN carotid arteries.

<p><b><i>A</i>:</b> a representative trace showing the relaxation evoked by iloprost (0.3–1 μM) in L-NAME-treated HTN arteries pre-contracted with 0.3 μM PE in the presence of 3 μM TP receptor antagonist SQ29548 (SQ). <b><i>B</i>:</b> comparison of the relaxation evoked by 0.3–1 μM iloprost (with SQ) in HTN and NTN arteries. <b><i>C</i>:</b> effects of IP receptor antagonist CAY10441 (+CAY; 1 μM) on similar extent of contractions evoked by AA (3 μM) and ACh (0.3 μM) in L-NAME-treated HTN arteries. <b><i>D</i>:</b> responses evoked by the TP receptor agonist U46619 in L-NAME-treated HTN and NTN arteries. In B, C and D, values were expressed as mean ± SEM. (n = 5 for each); * P<0.05 and ** P<0.01.