Nucleosome occupancy and cancer mutations.

<p><b>A</b>, Cancer non-coding mutation rate (MR) in relation to nucleosome occupancy scores (NOS) with a Pearson’s correlation coefficient (PCC) of 0.833. Bottom x-axis corresponds to the bar graph depicting the NOS for 10 equally sized groups of increasing nucleosome occupancy. Top x-axis corresponds to the scatter plot depiction of the same data for each individual NOS. <b>B</b>, Raw counts of Cancer SNVs in relation to dyads. <b>C</b>, Cancer indel and microindel counts in relation to absolute distance to nearest dyad. Two small enrichments of indels are at 74 and 115 bp which correspond to the theoretical start and end locations of linker DNA between two nucleosomes. <b>D</b>, The total cancer (coding and non-coding) mutation rate as a function of NOS, Pearson’s correlation coefficient (PCC) of 0.989. Bottom x-axis corresponds to the bar graph depicting the NOS for 10 equally sized groups of increasing nucleosome occupancy. Top x-axis corresponds to the scatter plot depiction of the same data for each individual NOS.