<p>(A) Media alone or <i>S</i>. <i>pneumoniae-</i>containing media was added to the lower chamber of HUVEC-seeded Transwell dishes for 3 hours. Transmigration of PMNs added to the upper chamber in media containing vehicle control or increasing concentrations of the CD73 inhibitor α,β- methylene ADP (left panel) or pan-adenosine receptor (AR) inhibitor CGS 15943 (right panel) was measured using a hemocytometer. The means +/- SEM from one representative of three experiments are shown and values significantly different from media control, determined by student’s t-test, are indicated by asterisk (*** = <i>p</i>< 0.0001; ** = <i>p</i>< 0.001; * = <i>p</i><0.05). (B) Polarized H292 epithelial cells, pre-treated with increasing concentrations CD7...
A. Representative fluorescence microscopy images of TUNEL staining of HIO and PMN-HIO histology sect...
<p><b>(A-D)</b> iHIOs microinjected with saline or 10<sup>3</sup> commensal bacteria or O157:H7 in t...
<p>HUVEC cells were treated with 2 µM rMASP-1, or left untreated for 30 minutes. Then, the medium wa...
<p>Wild-type untreated, mock-treated or CD73-inhibited C57BL/6 mice and CD73-ablated (<i>CD73</i><su...
<p><b>A</b>) PMN transmigration studies were performed in transwells using fMLP as chemoattractant i...
<p>HUVECd were stimulated with CM-Control, CM−LPS, CM−Stx1 or CM−LPS+Stx1 for 24 h. Then, PMN were s...
A. Transmigration of PMNs into the lumen of HIOs was quantified using flow cytometry. HIOs were micr...
<p>(A-D) Wild-type C57BL/6J mice were either treated with the CD73 inhibitor (α,β- methylene ADP), t...
(A) Human pulmonary lung EC were exposed to indicated concentrations of PM and TER was measured acro...
<p>(A) The involvement of ERK1/2 and PI3K pathways in IL8-induced migration was confirmed by measuri...
<p>Panels A,B: In cytomix-stimulated PMN/PMVEC co-cultures, PMVEC permeability and PMN migration wer...
<p>(A) Migration of neutrophil cell lines through transwells seeded with mouse endothelial cells. PM...
<div><p>An important determinant of disease following <i>Streptococcus pneumoniae</i> (pneumococcus)...
Neutrophil [polymorphonuclear leukocyte (PMN)] transepithelial migration (TEM) is a hallmark of infl...
<p>(A) When PDG<sub>2</sub> was perfused across a population of neutrophils adherent to EPA-treated ...
A. Representative fluorescence microscopy images of TUNEL staining of HIO and PMN-HIO histology sect...
<p><b>(A-D)</b> iHIOs microinjected with saline or 10<sup>3</sup> commensal bacteria or O157:H7 in t...
<p>HUVEC cells were treated with 2 µM rMASP-1, or left untreated for 30 minutes. Then, the medium wa...
<p>Wild-type untreated, mock-treated or CD73-inhibited C57BL/6 mice and CD73-ablated (<i>CD73</i><su...
<p><b>A</b>) PMN transmigration studies were performed in transwells using fMLP as chemoattractant i...
<p>HUVECd were stimulated with CM-Control, CM−LPS, CM−Stx1 or CM−LPS+Stx1 for 24 h. Then, PMN were s...
A. Transmigration of PMNs into the lumen of HIOs was quantified using flow cytometry. HIOs were micr...
<p>(A-D) Wild-type C57BL/6J mice were either treated with the CD73 inhibitor (α,β- methylene ADP), t...
(A) Human pulmonary lung EC were exposed to indicated concentrations of PM and TER was measured acro...
<p>(A) The involvement of ERK1/2 and PI3K pathways in IL8-induced migration was confirmed by measuri...
<p>Panels A,B: In cytomix-stimulated PMN/PMVEC co-cultures, PMVEC permeability and PMN migration wer...
<p>(A) Migration of neutrophil cell lines through transwells seeded with mouse endothelial cells. PM...
<div><p>An important determinant of disease following <i>Streptococcus pneumoniae</i> (pneumococcus)...
Neutrophil [polymorphonuclear leukocyte (PMN)] transepithelial migration (TEM) is a hallmark of infl...
<p>(A) When PDG<sub>2</sub> was perfused across a population of neutrophils adherent to EPA-treated ...
A. Representative fluorescence microscopy images of TUNEL staining of HIO and PMN-HIO histology sect...
<p><b>(A-D)</b> iHIOs microinjected with saline or 10<sup>3</sup> commensal bacteria or O157:H7 in t...
<p>HUVEC cells were treated with 2 µM rMASP-1, or left untreated for 30 minutes. Then, the medium wa...