Development of M1 dependent fibrosis in IFNγR-/- C57Bl/6 mice correlates with timing and kinetics of Vβ4⁺ CD8⁺ T cell expansion.

<p>8–12 week old IFNγR-/- C57Bl/6 mice were intranasally infected with 1x10⁵ pfu MHV68 (WT or M1st) or were mock infected and sacrificed at indicated times (n = 1–13 mice/group from one or two independent experiments). Right and accessory lobes were harvested and assessed for hydroxyproline content at days 4, 9, 28, and 90 post-infection. Statistics were performed using Mann-Whitney 2 tailed test to compare WT and M1st (* <i>P</i> = 0.0159, *** <i>P</i> = 0.0008).