Pten and Rb co-deletion in osteoblast precursor cells causes rapid lipoma but not osteosarcoma tumor onset.

<p>(A) H&E staining of sections from lipoma tumors derived from <i>Osx-Cre; Rb1</i>^<i>fl/fl</i>; <i>Pten</i>^<i>fl/fl</i> mice. Scale bars, 200 μM (Left), 50 μM (Right). (B) Kaplan-Meier survival curve analysis for the indicated genotypes: <i>Osx-Cre</i> (n = 21), <i>Osx-Cre; Rb1</i>^<i>fl/fl</i>; <i>p107</i>^<i>-/-</i> (n = 37), <i>Osx-Cre; Pten</i>^<i>fl/fl</i> (n = 17), <i>Osx-Cre; Rb1</i>^<i>fl/+</i>; <i>Pten</i>^<i>fl/fl</i> (n = 43), and <i>Osx-Cre; Rb1</i>^<i>fl/fl</i>; <i>Pten</i>^<i>fl/fl</i> (n = 37). <i>p</i>-values were determined by log rank test comparing a genotype with that of the control mice. *, <i>p</i> < 0.05; **, <i>p</i> < 0.01; ***, <i>p</i> < 0.005; N.S., not significant.