Comparison of Energy Landscapes Obtained by SIfTER for each H-Ras sequence.

<p>Obtained Rosetta and AMBER energy landscapes are shown for WT, G12V, and Q61L H-Ras. The location of the inactive and active structural states of H-Ras are indicated by the respective <i>On</i> and <i>Off</i> annotations. Other structural states corresponding to novel, observed basins in the landscapes are annotated by <i>Conf1</i> and <i>Conf2</i>.