Concentration of nucleotide precursors in whole saliva samples of human adults, term neonates, and domesticated mammals.

<p>(A) Healthy non-smoking adults (n = 77) and (B) healthy full-term vaginally-delivered neonates (n = 60), lines show median values. Non-parametric analyses were conducted to estimate the significance using a Mann-Whitney U test, (C) Longitudinal study of median concentrations of metabolites in saliva from full-term neonates aged 1–4 days (n = 60), 6 weeks (n = 20), 6 months (n = 19), and 12 months (n = 14), (D) Median metabolite concentrations in saliva from selected domesticated mammals (8 cows, 5 sheep, 4 goats, 5 horses, 1 camel, 7 dogs, 5 cats). Metabolites were divided into five functional groups: Pyrimidines (Pseudouridine to Orotate); Purine bases (Hypoxanthine, Xanthine); Purine nucleosides (Inosine, Guanosine); ATP precursors (Adenine, Adenosine); Deoxynucleosides (Deoxyadenosine to Deoxyuridine).