TIMP-2 interaction with MT1-MMP activates pro- or anti-apoptotic signaling depending on context.

<p>Western blotting analysis of PARP degradation (PARP p85) and MT1-MMP expression in MT1-MMP Tet-Off MCF-7 cells grown for 7 days in (<b>A</b>) 3D collagen gel or (<b>B</b>) on plastic, in the presence (-MT) or absence (+MT) of DOX with (+) or without (-) TIMP-2 (100 ng/ml). Beta tubulin (TUB) is shown as a loading control. <b>C and D</b>. Densitometric analysis. *, <i>p</i> ≤ 0.05. This experiment was repeated twice with comparable results.