Growth rates of isolated clones from the end-point populations of (a) strain E and (b) strain F. Growth rates of each 10 isolated clones and population under 5Â % ethanol stress conditions are presented with that of the parent strain. Error bars indicate standard deviations calculated from three independent cultures. In both strain E and strain F, no significant difference was observed between the growth rates of population and clones (analyzed by one-way ANOVA). (PDF 969Â kb
Diauxic growth in DM250 medium containing glucose and acetate at 10:90 ratio. Clone 6.5KS1 (red) exh...
Figure S8. Correlation between genome size and Ne for each lifestyle category. Genome size for a giv...
Figure S6. Impact of recombination on estimates of effective population size. Relationship between r...
Correlations between gene expression changes for all possible pairs of tolerant strains. Each axis r...
Reproducibility of (a) transcriptome analysis, (b) metabolome analysis. Horizontal and vertical axis...
(CSV 876Â kb)Time series expression analysis. The expression levels of 6 independent culture series ...
(CSV 3Â kb)Â Point mutations and indels found in the parent strains in comparison with W3110 referen...
(CSV 7Â kb)Intracellular metabolite concentrations in the parent and tolerant strains
Sequence coverage of strain C. The number of mapped sequencing reads of Illumina analysis is plotted...
Expression changes of genes related to (a) arginine, (b) methionine, and (c) histidine biosynthesis ...
Hybrid growth did not slow-down during ethanol stress. (A) For the S. cerevisiae pool, long-term sur...
Metabolite concentrations in de novo and salvage purine biosynthesis. In each inset, the vertical ax...
The number of non-synonymous mutations in coding regions in the evolved clones for each experimental...
Figure S4. Correlation between growth rate and effective population size computed from species’ core...
Expression changes of genes related to the biosynthesis of phosphoribosyl pyrophosphate (PRPP) in to...
Diauxic growth in DM250 medium containing glucose and acetate at 10:90 ratio. Clone 6.5KS1 (red) exh...
Figure S8. Correlation between genome size and Ne for each lifestyle category. Genome size for a giv...
Figure S6. Impact of recombination on estimates of effective population size. Relationship between r...
Correlations between gene expression changes for all possible pairs of tolerant strains. Each axis r...
Reproducibility of (a) transcriptome analysis, (b) metabolome analysis. Horizontal and vertical axis...
(CSV 876Â kb)Time series expression analysis. The expression levels of 6 independent culture series ...
(CSV 3Â kb)Â Point mutations and indels found in the parent strains in comparison with W3110 referen...
(CSV 7Â kb)Intracellular metabolite concentrations in the parent and tolerant strains
Sequence coverage of strain C. The number of mapped sequencing reads of Illumina analysis is plotted...
Expression changes of genes related to (a) arginine, (b) methionine, and (c) histidine biosynthesis ...
Hybrid growth did not slow-down during ethanol stress. (A) For the S. cerevisiae pool, long-term sur...
Metabolite concentrations in de novo and salvage purine biosynthesis. In each inset, the vertical ax...
The number of non-synonymous mutations in coding regions in the evolved clones for each experimental...
Figure S4. Correlation between growth rate and effective population size computed from species’ core...
Expression changes of genes related to the biosynthesis of phosphoribosyl pyrophosphate (PRPP) in to...
Diauxic growth in DM250 medium containing glucose and acetate at 10:90 ratio. Clone 6.5KS1 (red) exh...
Figure S8. Correlation between genome size and Ne for each lifestyle category. Genome size for a giv...
Figure S6. Impact of recombination on estimates of effective population size. Relationship between r...