Additional file 2: Figure S2. of IL2RA is associated with persistence of rheumatoid arthritis

Showing genetic variants in relation to achieving DMARD-free sustained remission in ACPA-positive and ACPA-negative RA patients from the Leiden EAC cohort. SE in ACPA-positive: HR per SE allele = 0.92 (95 % CI = 0.42–2.03). SE in ACPA-negative: HR per SE allele = 0.89 (95 % CI = 0.63–1.25). rs2104286 (IL2RA) in ACPA-positive: HR per minor allele = 1.82 (95 % CI = 0.88–3.77). rs2104286 (IL2RA) in ACPA-negative: HR per minor allele = 1.41 (95 % CI = 1.05–1.89). All analyses were adjusted for age, gender, and inclusion period (as proxy for treatment strategy). Note that the y axes of the ACPA-positive and ACPA-negative subgroups are different. (PDF 218 kb