Supplementary_Figures

<p>Supp Fig 1 Methylation difference between recurrence vs initial. Log fold-change of methylation difference between recurrence and initial tumor show that the frequency [a1] of probes that have an absolute difference of 20% is less than 5 (dotted line at absolute fold-change of 10%).</p> <p>Supp Fig 2 Beta methylation values in PAX3 gene region at initial tumor (blue) and at first recurrence (red). The beta values are significantly different in PAX3 promoter region. The first panel shows beta methylation values according to genomic position, the second panel shows a representation of PAX3 transcript according to UCSC, the third panel shows CpG islands within PAX3 region and the fourth panel the beta values per sample and per probe, illustrated as a heatmap (blue 0, hypomethylated and red 1, hypermethylated).</p> <p>Supp Fig 3 Treemap of the GO processes represented by the most differentially methylated genes comparting initial tumor vs first recurrence. GO processes are ordered according to frequency and p-values.</p> <p>Supp Fig 4 Treemap of the GO processes represented by the most differentially methylated genes comparting first recurrence vs second recurrence. GO processes are ordered according to frequency and p-values.