Inspired by the biosynthesis of sesquiterpene lactones (SLs), herein we report the asymmetric total synthesis of the germacrane ring (<b>24</b>). The synthetic strategy features a selective aldol reaction between β,γ-unsaturated chiral sulfonylamide <b>15a</b> and aldehyde <b>13</b>, as well as the intramolecular α-alkylation of sulfone <b>21</b> to construct a 10-membered carbocylic ring. The key intermediate <b>24</b> can be used to prepare the natural products costunolide and parthenolide (PTL), which are the key precursors for transformation into other SLs. Furthermore, the described synthetic sequences are amenable to the total synthesis of SL analogues, such as trifluoromethylated analogues <b>32</b> and <b>45</b>. Analogues <b>32</b>...
Department of Chemistry, Indian Institiite of Technology, Powai, Bombay-400 076 Department of Chemi...
In 2005 two research groups independently reported the isolation of a series of structurally intrigu...
The first asymmetric total syntheses of sesquiterpene lactones (+)-eudesmadiene-12,6-olide (<b>1</b>...
Inspired by the biosynthesis of sesquiterpene lactones (SLs), herein we report the asymmetric total ...
Parthenolide showed extensive bioactivities including selective eradication of AML stem cells. Herei...
The natural product parthenolide is a sesquiterpene lactone isolated from the anti-inflammatory medi...
The sesquiterpene costunolide has a broad range of biological activities and is the parent compound ...
Parthenolide is the major bioactive compound of feverfew and has anti-inflammatory and anti-cancer a...
Chicory (Cichorium intybus) is known to contain guaianolides, eudesmanolides, and germacranolides. T...
The first total synthesis of parthenolide (<b>1</b>) is described. The key feature of this synthesis...
Diverse natural product carbocycles and heterocycles are continuously of interest to the biochemical...
The synthesis and the biological evaluation of a new family diterpenes are presented. The synthetic ...
Chapter One. Anthecularin is a new antimalarial sesquiterpene lactone, which was iso-lated from Ant...
This dissertation highlights studies into the total synthesis of C-glycoside natural products via ox...
The total synthesis of natural products allows organic chemists the opportunity to develop new metho...
Department of Chemistry, Indian Institiite of Technology, Powai, Bombay-400 076 Department of Chemi...
In 2005 two research groups independently reported the isolation of a series of structurally intrigu...
The first asymmetric total syntheses of sesquiterpene lactones (+)-eudesmadiene-12,6-olide (<b>1</b>...
Inspired by the biosynthesis of sesquiterpene lactones (SLs), herein we report the asymmetric total ...
Parthenolide showed extensive bioactivities including selective eradication of AML stem cells. Herei...
The natural product parthenolide is a sesquiterpene lactone isolated from the anti-inflammatory medi...
The sesquiterpene costunolide has a broad range of biological activities and is the parent compound ...
Parthenolide is the major bioactive compound of feverfew and has anti-inflammatory and anti-cancer a...
Chicory (Cichorium intybus) is known to contain guaianolides, eudesmanolides, and germacranolides. T...
The first total synthesis of parthenolide (<b>1</b>) is described. The key feature of this synthesis...
Diverse natural product carbocycles and heterocycles are continuously of interest to the biochemical...
The synthesis and the biological evaluation of a new family diterpenes are presented. The synthetic ...
Chapter One. Anthecularin is a new antimalarial sesquiterpene lactone, which was iso-lated from Ant...
This dissertation highlights studies into the total synthesis of C-glycoside natural products via ox...
The total synthesis of natural products allows organic chemists the opportunity to develop new metho...
Department of Chemistry, Indian Institiite of Technology, Powai, Bombay-400 076 Department of Chemi...
In 2005 two research groups independently reported the isolation of a series of structurally intrigu...
The first asymmetric total syntheses of sesquiterpene lactones (+)-eudesmadiene-12,6-olide (<b>1</b>...