Effects of menthol pretreatment on nicotine-induced antinociception and hypothermia dose-response curves in mice.

<p>Vehicle or menthol (100 mg/kg, ip) was administered 30 min before various doses of nicotine (0.5, 1.5, 2, and 2.5 mg/kg s.c.) and mice were tested in <b>(A)</b> the tail-flick test, <b>(B)</b> the hot-plate test, and <b>(C)</b> hypothermia. Each point represents the mean ± SE of 8–12 mice.