Effects of menthol on the time course of nicotine’s effects in (A) the tail-flick test, (B) the hot-plate assay, and (C) body temperature in mice.

<p>Animals were pretreated with either menthol (100 mg/kg i.p.) or vehicle and 30 min later received nicotine (2.5 mg/kg, s.c.). A control group (vehicle/vehicle) is also represented in all three tests. Mice were tested at different time points after injection. Each point represents the mean ± SE of 8–12 mice. *p < 0.05 compared with vehicle/nicotine group.