Skeletal tumors in <i>Ptprz1</i>-deficient <i>Trp53</i>-heterozygous mice.
- Christina Baldauf (794217)
- Anke Jeschke (297345)
- Vincent Kanbach (794218)
- Philip Catala-Lehnen (5665024)
- Daniel Baumhoer (451746)
- Helwe Gerull (794219)
- Sophia Buhs (794220)
- Michael Amling (133377)
- Peter Nollau (338092)
- Sheila Harroch (203857)
- Thorsten Schinke (126724)
Publication date
September 2015
DOIAbstract
<p>(A) OS development assessed by screening of 12 month old <i>Trp53</i>-heterozygous mice with the indicated <i>Ptprz1</i> genotypes. The left panel shows the number of analyzed mice (white bars) and the percentage of mice with OS (black bars). The asterisk indicates statistical significance vs. <i>Trp53</i><sup><i>+/-</i></sup><i>/Ptprz1</i><sup><i>+/+</i></sup> (p<0.05, two-tailed Fishers`s exact test). The right panel shows the total number of tumors and their location. (B) Representative contact Xrays from <i>Ptprz1</i>-deficient <i>Trp53</i>-heterozygous mice with OS in the three different locations. (C) μCT images from the same tumors.</p
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