FSHR-1 is required for the defense against diverse pathogens.

<p>Representative wild-type (A) and <i>fshr-1(ok778)</i> mutant (B) worms fed GFP-PA14 for 18 hours. Scale bars = 100 μm. (C) Quantification of the sum of the intestinal fluorescence intensity for at least 10 representative individual worms per condition. (D) Mean survival time of wild-type and <i>fshr-1(ok778)</i> mutant worms exposed to different bacterial food sources. * P<0.05, **P<0.01, *** P<0.0001 in unpaired t-test. Error bars are SEM. (E) Functional annotation of genes whose mean expression from three microarray replicates in wild-type worms infected with PA14 for 4 hours was at least 2-fold higher than their mean expression in <i>fshr-1(ok778)</i> mutants infected with PA14 for 4 hours, with P<0.05. Genes known to be involved both in infection response and stress response were grouped with stress response.