CNAs according to Lauren’s classification.

<p>(A-B) Correlations of log2 ratio of DNA copy number and mRNA fold change (FC) of <i>FHIT</i> (A) and <i>BOP1</i> (B) in tumor tissues compared to matched normal tissues were analyzed using Pearson’s correlation coefficients. Different color circles indicate different samples. (C-E) The differences in prevalence of copy number alterations of multiple genes were compared between diffuse-type cancers and intestinal-type cancers using Pearson’s chi-square test. Copy number gains of <i>MYC</i> (<i>P</i> = 0.03), <i>BOP1</i> (<i>P</i> = 0.03), and <i>CD40</i> (<i>P</i> = 0.01) occurred at a high prevalence in intestinal-type cancers compared to diffuse-type cancers. In general, copy number gains tend to occur more frequently in intestinal-type cancers than in diffuse-type cancers.