Correlations of CNAs levels with patient’s age at diagnosis and other CNAs in different chromosomal regions.

<p>(A) Correlations of CNAs levels with patient’s age were analyzed using Pearson’s correlation coefficient. Multiple tests were corrected using the Bonferroni correction. The Bonferroni-corrected <i>P</i>-values were calculated by multiplying the observed (uncorrected) <i>P</i>-values by the number of tested genes. Violet colors indicate Bonferroni-adjusted <i>P-</i>value < 0.05. (B) Unsupervised hierarchical clustering analysis of 15 genes in regions with recurrent (>20%) CNAs was performed to investigate correlations among CNAs levels of 11 genes showing copy number gains on 8q24.21, 8q24.3, 20q11.21, and 20q13.12, and 4 genes showing copy number losses. The numbers on the right side of the figure indicate patient identification number. The color scales indicate log2 intensity ratios of CNAs at individual gene. Value “zero (= log(2/2)” indicate a copy number of 2. Green and red colors represent copy number gain and loss, respectively.