Additional file 11: Figure S7. of Gene expression meta-analysis reveals immune response convergence on the IFNÎł-STAT1-IRF1 axis and adaptive immune resistance mechanisms in lymphoma

Relates to Fig. 4. Genes most consistently associated with COO-unclassified DLBCL are related to a polarized immune response. As in Fig. 4, the two principal branches of the gene-centred hierarchical clustering tree of the COO-unclassified meta-profile are illustrated on the left. Colour-coding above identifies: red cluster 1, corresponding to the T-cell cluster; black cluster 2, IFN and monocyte/immune NOS (not otherwise specified). On the right the relative rank of differentially expressed genes contributing to the COO-unclassified meta-profile is plotted using the median normalized fold change for gene ranking; the x-axis indicates differential expression rank in the comparison COO-unclassified versus ABC-DLBCL; the y-axis indicates differential expression rank in the comparison COO-unclassified versus GCB-DLBCL. Cluster membership is superimposed on the scatter plot of differential expression rank according to the colour coding shown (red cluster 1, black cluster 2). The 18 genes most consistently separating COO-unclassified DLBCL from either ABC- or GCB-DLBCL are illustrated below with cluster membership and mean differential expression rank shown. (PDF 275 kb