<p>[A] Total CD4 T cell numbers and numbers of CD4 cells staining positive for IFNg. [B] Total CD8 T cell numbers and numbers of CD8 cells staining positive for IFNg. [C] Numbers of CD4 cells staining positive for IL-17A/F. Data is shown for saline controls [closed squares] and in mice previously vaccinated subcutaneously with BCG Pasteur [open circles] or rBCG Aeras 422 [open squares] [n = 4/5 mice ± SEM].</p
<p>B6 (wild type) or IFITM3 KO mice were seeded with naïve CFSE-labeled OT-I.CD45.1 one day prior in...
<p>(A) the amino acid sequence of the TB10.4 protein with the CD4 and CD8 T cell epitopes underlined...
<p>WTC: wild-type control group; KOC: CXCR3KO control group; WTP: wild-type HDMP test group; KOP: CX...
<p>(A) Percentage of T cells (defined as CD3<sup>+</sup>) in the BAL fluid from mice infected with 5...
<p>Draining lymph node cells from all groups were stimulated <i>in vitro</i> with anti-CD3 and anti-...
<p>The dot plots show representative data from healthy control subjects, illustrating the analysis m...
(A) 2x107 T cells, isolated from wild-type, Ifng-/-, Ifngr1-/- or Prf1-/- donors, or 1x107 CD4 T cel...
<p>Spleens were collected at each time point from xenotransplanted mice (day 1, 3, 6, 11, 16, and 30...
<p>Lung lymphocytes from mice sacrificed at different stages of infection (Early: week 6; late: week...
<p>(A) Flow cytometry analysis for the expression of IL-1β, TGF-β, IL-6 and IL-23 cytokines on CD4+g...
<p>WT C57BL/6 mice or IL-21R KO mice were infected with 0.1 LD<sub>50</sub> PR8 and lung cell suspen...
<p>Lungs from infected C57BL/6J mice (2×10<sup>3</sup> FFU) were extracted and cell suspensions were...
<p>Mice (n = 12/group) were infected i.n. with 10<sup>4</sup> PFU of V<sub>K627</sub> (▪), rV<sub>K6...
<p>A) Flow cyotmetric plots showing CD8 versus CD3 staining after gating on lymphocytes by forward a...
<p>C57BL/6 and CBA/J mice were infected with an aerosolized dose of <i>Mtb</i> and at various timepo...
<p>B6 (wild type) or IFITM3 KO mice were seeded with naïve CFSE-labeled OT-I.CD45.1 one day prior in...
<p>(A) the amino acid sequence of the TB10.4 protein with the CD4 and CD8 T cell epitopes underlined...
<p>WTC: wild-type control group; KOC: CXCR3KO control group; WTP: wild-type HDMP test group; KOP: CX...
<p>(A) Percentage of T cells (defined as CD3<sup>+</sup>) in the BAL fluid from mice infected with 5...
<p>Draining lymph node cells from all groups were stimulated <i>in vitro</i> with anti-CD3 and anti-...
<p>The dot plots show representative data from healthy control subjects, illustrating the analysis m...
(A) 2x107 T cells, isolated from wild-type, Ifng-/-, Ifngr1-/- or Prf1-/- donors, or 1x107 CD4 T cel...
<p>Spleens were collected at each time point from xenotransplanted mice (day 1, 3, 6, 11, 16, and 30...
<p>Lung lymphocytes from mice sacrificed at different stages of infection (Early: week 6; late: week...
<p>(A) Flow cytometry analysis for the expression of IL-1β, TGF-β, IL-6 and IL-23 cytokines on CD4+g...
<p>WT C57BL/6 mice or IL-21R KO mice were infected with 0.1 LD<sub>50</sub> PR8 and lung cell suspen...
<p>Lungs from infected C57BL/6J mice (2×10<sup>3</sup> FFU) were extracted and cell suspensions were...
<p>Mice (n = 12/group) were infected i.n. with 10<sup>4</sup> PFU of V<sub>K627</sub> (▪), rV<sub>K6...
<p>A) Flow cyotmetric plots showing CD8 versus CD3 staining after gating on lymphocytes by forward a...
<p>C57BL/6 and CBA/J mice were infected with an aerosolized dose of <i>Mtb</i> and at various timepo...
<p>B6 (wild type) or IFITM3 KO mice were seeded with naïve CFSE-labeled OT-I.CD45.1 one day prior in...
<p>(A) the amino acid sequence of the TB10.4 protein with the CD4 and CD8 T cell epitopes underlined...
<p>WTC: wild-type control group; KOC: CXCR3KO control group; WTP: wild-type HDMP test group; KOP: CX...