NOV expression in renal cortex and plasma after UUO.

<p>(A) RT-qPCR analysis in the renal cortex showed increased expression of NOV mRNA after 3, 7 and 15 days of UUO compared to contralateral cortex. Values are means ± SEM and expressed as the ratio of the target gene to the internal control gene (S26 rRNA). n = 7 for each group. *<i>P</i><0.05 and ***<i>P</i><0.001, UUO vs. ctrl, #P<0.05, WT ctrl versus Nov-/- ctrl. (B) Quantification of NOV concentration by ELISA showed an increased expression of NOV in plasma after 7 days of UUO compared to sham mice. Values are means ± SEM in ng/mL. n = 9 for sham animals and 4 for both UUO time points. ***<i>P</i> <0.001, UUO vs. sham.