Node centralities in the MAMMOTH network at a probability threshold of 0.6.

<p>For each measure of centrality sets of folds with high and low centralities are identified as described in the Methods. These sets are shown projected onto the network. Low centralities are coloured in blue. High centralities are shaded from red (lowest) to yellow (highest). Nodes with intermediate centralities which are not counted as either central or peripheral are shown in grey. Also shown is a cumulative percentile plot for the fold ages of central and peripheral nodes. These graphs show a preference for central nodes to be older than peripheral folds. a) Node centrality by degree. b) Node centrality by closeness. c) Node centrality by betweenness.