Expression of Cyp7a1 transcription regulators in liver and ileum.

<p>The mRNAs of key factors that regulate basal Cyp7a1 transcription (HNF4α, LRH-1, and PGC-1α) and BA-feedback inhibition of Cyp7a1 transcription (both FXR-SHP in liver and FXR-Fgf15 in ileum) were quantified in (A) liver and (B) intestine. Data are presented as means ± SEM of 5 mice. The triangle represents increased expression of Sirt1 in liver. # represents differences compared to WT mice, by one-way ANOVA, followed by Duncan’s post-hoc test (<i>p</i> < 0.05). * represents differences compared to AL mice of the same genotype by Student's <i>t</i>-test (<i>p</i> < 0.05).