Additional file 2: Figure S2. of Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors

Additional file 9: of Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Karin Hjorton (5894399)
Niklas Hagberg (4395256)
Elisabeth Israelsson (3805228)
Lisa Jinton (5487662)
Olof Berggren (4395247)
Johanna Sandling (3499334)
Kristofer Thรถrn (5894459)
John Mo (5894411)
Maija-Leena Eloranta (101880)
Lars Rรถnnblom (5894468)

October 2018

Figure S6. Overlap of differentially expressed genes in plasmacytoid dendritic cells. (PDF 135 kb

Additional file 3: of Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Michael Dumbacher (5795363)
Tom Van Dooren (5795366)
Katrien Princen (2304022)
Koen De Witte (5795369)
Mélissa Farinelli (174681)
Sam Lievens (439826)
Jan Tavernier (31436)
Wim Dehaen (496141)
Stefaan Wera (5795372)
Joris Winderickx (23642)
Sara Allasia (5795375)
Amuri Kilonda (2688319)
Stéphane Spieser (5795378)
Arnaud Marchand (1656289)
Patrick Chaltin (1656292)
Casper Hoogenraad (3465326)
Gerard Griffioen (5795381)

September 2018

Figure S2. Reduction in Ca2+ influx through VGCCs reduces ATRA induced toxicity. a The effect of isr...

Additional file 1: of Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis

T. Zhang (1410247)
A. Kastrenopoulou (5185808)
Q. Larrouture (5185802)
N. Athanasou (5185805)
H. Knowles (5185811)

May 2018

Figure S1. ANGPTL4 knock-down has no phenotypic effect under standard cell culture conditions. (DOCX...

Additional file 1: Figure S1. of Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors

Miguel Perez-Aso (3567833)
M. Montesinos (3567836)
Aránzazu Mediero (3567842)
Tuere Wilder (3567839)
Peter Schafer (2384476)
Bruce Cronstein (3567830)

September 2015

Adenosine A2A receptor (A2AR) activation and apremilast do not additively increase responsive elemen...

Additional file 2: of Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Karin Hjorton (5894399)
Niklas Hagberg (4395256)
Elisabeth Israelsson (3805228)
Lisa Jinton (5487662)
Olof Berggren (4395247)
Johanna Sandling (3499334)
Kristofer Thรถrn (5894459)
John Mo (5894411)
Maija-Leena Eloranta (101880)
Lars Rรถnnblom (5894468)

October 2018

Figure S1. Titration of IRAK4 inhibitor (I92) on cytokine production by cocultured plasmacytoid dend...

Additional file 1: of Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4

Koichi Fujisawa (759749)
Shuji Terai (496086)
Taro Takami (742001)
Naoki Yamamoto (200072)
Takahiro Yamasaki (741995)
Toshihiko Matsumoto (741998)
Kazuhito Yamaguchi (3509492)
Yuji Owada (36388)
Hiroshi Nishina (334827)
Takafumi Noma (527171)
Isao Sakaida (156599)

March 2016

Supplemenal Fig. 1 Evaluation of adenylate kinase 4 (AK4) in A549 cells. (A) Western blotting evalua...

Additional file 1: Figure S1. of Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13

Cristiane Bentin Toaldo (3585044)
Xanthippi Alexi (1973728)
Karin Beelen (3585041)
Marleen Kok (3585053)
Michael Hauptmann (56178)
Maurice Jansen (3525374)
Els Berns (3525377)
Jacques Neefjes (116151)
Sabine Linn (832377)
Rob Michalides (3585050)
Wilbert Zwart (3585047)

August 2015

siRNA targeting AKAP95 does not influence PKA-induced ERαS305 phosphorylation. MCF-7 breast cancer c...

Additional file 2: of MIIP inhibits the growth of prostate cancer via interaction with PP1Îą and negative modulation of AKT signaling

Guang Yan (311657)
Yi Ru (500304)
Fengqi Yan (5700782)
Xin Xiong (113595)
Wei Hu (6560)
Tao Pan (22600)
Jianming Sun (6704741)
Chi Zhang (9857)
Qinghao Wang (6684815)
Xia Li (14984)

May 2019

Figure S1. Endogenous MIIP expression in different prostate cancer cell lines. Cells were lysed and ...

Additional file 5: Figure S4. of HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Qiuran Xu (4103755)
Jianfeng Tu (4103758)
Changwei Dou (3554573)
Jun Zhang (48506)
Liu Yang (23752)
Xin Liu (43569)
Kefeng Lei (4708894)
Zhikui Liu (3554570)
Yufeng Wang (274657)
Lijie Li (1438762)
Hangxing Bao (4103752)
Jiahui Wang (746367)
Kangsheng Tu (428934)

December 2017

HSP90 knockdown led to decreased Ser/Thr phosphorylation of PKM2. Hep3B cells were transfected with ...

Additional file 12: of Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Karin Hjorton (5894399)
Niklas Hagberg (4395256)
Elisabeth Israelsson (3805228)
Lisa Jinton (5487662)
Olof Berggren (4395247)
Johanna Sandling (3499334)
Kristofer ThĂśrn (5894546)
John Mo (5894411)
Maija-Leena Eloranta (101880)
Lars RĂśnnblom (5894549)

October 2018

Figure S7. RNA-seq analysis of cytokine expression in plasmacytoid dendritic cells stimulated for 6Â...

Additional file 3: Figure S2. of 3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response

Sharath Gangadhara (3535406)
Chris Smith (61664)
Peter Barrett-Lee (3535403)
Stephen Hiscox (361114)

June 2016

Effects of AKT and MAPK inhibition on apoptosis in BT474 and MDAMB361 cells. Cell lines grown in 2D ...

Additional file 2: of IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts

Carrie House (267929)
Valentina Grajales (5290823)
Michelle Ozaki (5290826)
Elizabeth Jordan (3540098)
Helmae Wubneh (5290829)
Danielle Kimble (5290835)
Jana James (5290832)
Marianne Kim (3540086)
Christina Annunziata (3540092)

May 2018

Figure S1. Protein activity suppressed by inhibitors. Western blot quantification and short time poi...

Additional file 2: of The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling

Philipp Berning (5237297)
Christiane Schaefer (4811433)
Dagmar Clemens (5237300)
Eberhard Korsching (387671)
Uta Dirksen (282783)
Jenny Potratz (4811430)

May 2018

Table S1. Plerixafor treatment changes receptor tyrosine kinase phosphorylation patterns in CXCR4-hi...

Additional file 2: Figure S2. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

I. Plastira (4706296)
E. Bernhart (4706311)
M. Goeritzer (4706302)
T. DeVaney (3465170)
H. Reicher (4706299)
A. Hammer (4706314)
B. Lohberger (4706305)
A. Wintersperger (4706323)
B. Zucol (4706317)
W. Graier (4706320)
D. Kratky (4706308)
E. Malle (3465176)
W. Sattler (4706293)

December 2017

PKD family inhibition abrogates LPA-mediated downstream signaling. (A) BV-2 microglia cells were cul...

Additional file 1: of ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination

Ying Zhang (1235337)
Yelong Chen (5327576)
Zhaoyong Liu (5327579)
Raymond Lai (102515)

May 2018

Figure S1. The expression of STAT1 in ESCC cell lines has no change via 5-Aza treatments. A. EC1, KY...

Additional file 9: of Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Karin Hjorton (5894399)
Niklas Hagberg (4395256)
Elisabeth Israelsson (3805228)
Lisa Jinton (5487662)
Olof Berggren (4395247)
Johanna Sandling (3499334)
Kristofer Thรถrn (5894459)
John Mo (5894411)
Maija-Leena Eloranta (101880)
Lars Rรถnnblom (5894468)

October 2018

Figure S6. Overlap of differentially expressed genes in plasmacytoid dendritic cells. (PDF 135 kb

Additional file 3: of Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Michael Dumbacher (5795363)
Tom Van Dooren (5795366)
Katrien Princen (2304022)
Koen De Witte (5795369)
Mélissa Farinelli (174681)
Sam Lievens (439826)
Jan Tavernier (31436)
Wim Dehaen (496141)
Stefaan Wera (5795372)
Joris Winderickx (23642)
Sara Allasia (5795375)
Amuri Kilonda (2688319)
Stéphane Spieser (5795378)
Arnaud Marchand (1656289)
Patrick Chaltin (1656292)
Casper Hoogenraad (3465326)
Gerard Griffioen (5795381)

September 2018

Figure S2. Reduction in Ca2+ influx through VGCCs reduces ATRA induced toxicity. a The effect of isr...

Additional file 1: of Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis

T. Zhang (1410247)
A. Kastrenopoulou (5185808)
Q. Larrouture (5185802)
N. Athanasou (5185805)
H. Knowles (5185811)

May 2018

Figure S1. ANGPTL4 knock-down has no phenotypic effect under standard cell culture conditions. (DOCX...

Additional file 1: Figure S1. of Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors

Miguel Perez-Aso (3567833)
M. Montesinos (3567836)
Aránzazu Mediero (3567842)
Tuere Wilder (3567839)
Peter Schafer (2384476)
Bruce Cronstein (3567830)

September 2015

Adenosine A2A receptor (A2AR) activation and apremilast do not additively increase responsive elemen...

Additional file 2: of Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Karin Hjorton (5894399)
Niklas Hagberg (4395256)
Elisabeth Israelsson (3805228)
Lisa Jinton (5487662)
Olof Berggren (4395247)
Johanna Sandling (3499334)
Kristofer Thรถrn (5894459)
John Mo (5894411)
Maija-Leena Eloranta (101880)
Lars Rรถnnblom (5894468)

October 2018

Figure S1. Titration of IRAK4 inhibitor (I92) on cytokine production by cocultured plasmacytoid dend...

Additional file 1: of Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4

Koichi Fujisawa (759749)
Shuji Terai (496086)
Taro Takami (742001)
Naoki Yamamoto (200072)
Takahiro Yamasaki (741995)
Toshihiko Matsumoto (741998)
Kazuhito Yamaguchi (3509492)
Yuji Owada (36388)
Hiroshi Nishina (334827)
Takafumi Noma (527171)
Isao Sakaida (156599)

March 2016

Supplemenal Fig. 1 Evaluation of adenylate kinase 4 (AK4) in A549 cells. (A) Western blotting evalua...

Additional file 1: Figure S1. of Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13

Cristiane Bentin Toaldo (3585044)
Xanthippi Alexi (1973728)
Karin Beelen (3585041)
Marleen Kok (3585053)
Michael Hauptmann (56178)
Maurice Jansen (3525374)
Els Berns (3525377)
Jacques Neefjes (116151)
Sabine Linn (832377)
Rob Michalides (3585050)
Wilbert Zwart (3585047)

August 2015

siRNA targeting AKAP95 does not influence PKA-induced ERαS305 phosphorylation. MCF-7 breast cancer c...

Additional file 2: of MIIP inhibits the growth of prostate cancer via interaction with PP1Îą and negative modulation of AKT signaling

Guang Yan (311657)
Yi Ru (500304)
Fengqi Yan (5700782)
Xin Xiong (113595)
Wei Hu (6560)
Tao Pan (22600)
Jianming Sun (6704741)
Chi Zhang (9857)
Qinghao Wang (6684815)
Xia Li (14984)

May 2019

Figure S1. Endogenous MIIP expression in different prostate cancer cell lines. Cells were lysed and ...

Additional file 5: Figure S4. of HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Qiuran Xu (4103755)
Jianfeng Tu (4103758)
Changwei Dou (3554573)
Jun Zhang (48506)
Liu Yang (23752)
Xin Liu (43569)
Kefeng Lei (4708894)
Zhikui Liu (3554570)
Yufeng Wang (274657)
Lijie Li (1438762)
Hangxing Bao (4103752)
Jiahui Wang (746367)
Kangsheng Tu (428934)

December 2017

HSP90 knockdown led to decreased Ser/Thr phosphorylation of PKM2. Hep3B cells were transfected with ...

Additional file 12: of Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Karin Hjorton (5894399)
Niklas Hagberg (4395256)
Elisabeth Israelsson (3805228)
Lisa Jinton (5487662)
Olof Berggren (4395247)
Johanna Sandling (3499334)
Kristofer ThĂśrn (5894546)
John Mo (5894411)
Maija-Leena Eloranta (101880)
Lars RĂśnnblom (5894549)

October 2018

Figure S7. RNA-seq analysis of cytokine expression in plasmacytoid dendritic cells stimulated for 6Â...

Additional file 3: Figure S2. of 3D culture of Her2+ breast cancer cells promotes AKT to MAPK switching and a loss of therapeutic response

Sharath Gangadhara (3535406)
Chris Smith (61664)
Peter Barrett-Lee (3535403)
Stephen Hiscox (361114)

June 2016

Effects of AKT and MAPK inhibition on apoptosis in BT474 and MDAMB361 cells. Cell lines grown in 2D ...

Additional file 2: of IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts

Carrie House (267929)
Valentina Grajales (5290823)
Michelle Ozaki (5290826)
Elizabeth Jordan (3540098)
Helmae Wubneh (5290829)
Danielle Kimble (5290835)
Jana James (5290832)
Marianne Kim (3540086)
Christina Annunziata (3540092)

May 2018

Figure S1. Protein activity suppressed by inhibitors. Western blot quantification and short time poi...

Additional file 2: of The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling

Philipp Berning (5237297)
Christiane Schaefer (4811433)
Dagmar Clemens (5237300)
Eberhard Korsching (387671)
Uta Dirksen (282783)
Jenny Potratz (4811430)

May 2018

Table S1. Plerixafor treatment changes receptor tyrosine kinase phosphorylation patterns in CXCR4-hi...

Additional file 2: Figure S2. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

I. Plastira (4706296)
E. Bernhart (4706311)
M. Goeritzer (4706302)
T. DeVaney (3465170)
H. Reicher (4706299)
A. Hammer (4706314)
B. Lohberger (4706305)
A. Wintersperger (4706323)
B. Zucol (4706317)
W. Graier (4706320)
D. Kratky (4706308)
E. Malle (3465176)
W. Sattler (4706293)

December 2017

PKD family inhibition abrogates LPA-mediated downstream signaling. (A) BV-2 microglia cells were cul...

Additional file 1: of ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination

Ying Zhang (1235337)
Yelong Chen (5327576)
Zhaoyong Liu (5327579)
Raymond Lai (102515)

May 2018

Figure S1. The expression of STAT1 in ESCC cell lines has no change via 5-Aza treatments. A. EC1, KY...

Additional file 9: of Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Karin Hjorton (5894399)
Niklas Hagberg (4395256)
Elisabeth Israelsson (3805228)
Lisa Jinton (5487662)
Olof Berggren (4395247)
Johanna Sandling (3499334)
Kristofer Thรถrn (5894459)
John Mo (5894411)
Maija-Leena Eloranta (101880)
Lars Rรถnnblom (5894468)

October 2018

Figure S6. Overlap of differentially expressed genes in plasmacytoid dendritic cells. (PDF 135 kb

Additional file 3: of Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Michael Dumbacher (5795363)
Tom Van Dooren (5795366)
Katrien Princen (2304022)
Koen De Witte (5795369)
Mélissa Farinelli (174681)
Sam Lievens (439826)
Jan Tavernier (31436)
Wim Dehaen (496141)
Stefaan Wera (5795372)
Joris Winderickx (23642)
Sara Allasia (5795375)
Amuri Kilonda (2688319)
Stéphane Spieser (5795378)
Arnaud Marchand (1656289)
Patrick Chaltin (1656292)
Casper Hoogenraad (3465326)
Gerard Griffioen (5795381)

September 2018

Figure S2. Reduction in Ca2+ influx through VGCCs reduces ATRA induced toxicity. a The effect of isr...

Additional file 1: of Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis

T. Zhang (1410247)
A. Kastrenopoulou (5185808)
Q. Larrouture (5185802)
N. Athanasou (5185805)
H. Knowles (5185811)

May 2018

Figure S1. ANGPTL4 knock-down has no phenotypic effect under standard cell culture conditions. (DOCX...

Additional file 2: Figure S2. of Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors

Abstract

Extracted data

Additional file 2: Figure S2. of Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors

Abstract

Extracted data

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