<p>The results from PCR sequencing of rs76418789 were placed on each member in the pedigree. The arrowheads indicated the SNV portion. Red colored variants were derived from the mother’s risk allele, whereas green colored ones were derived from father’s reference allele. The pedigree comprised healthy parents (father is indicated as ‘1’ and mother as ‘2’), a healthy second son (4), and older (3) and younger sons (5) affected by Crohn’s disease. Age is indicated in years (y) in the right margin.</p
Background: A large family of Moroccan immigrants was investigated. In this family the father develo...
The high frequency of familial Crohn's disease (CD) suggests a genetic predisposition. The most rece...
The common disease-common variant hypothesis is insufficient to explain the complexities of Crohn’s ...
<p>The pedigree comprised healthy parents (father is indicated as ‘1’ and mother as ‘2’), a healthy ...
Crohn’s disease is a complex genetic trait characterized by chronic relapsing intestinal inflammatio...
<p>Individuals for which DNA samples could be collected are represented in blue when unaffected and ...
<p>Putative risk haplotypes (shown in red and designated with a star) are shown for two families whe...
<p>Affected individuals are indicated with filled symbols and unaffected individuals are indicated w...
<p>(<b>A</b>) Map of the 5q31 risk locus containing –log(P) values of SNPs (CD SNPs), LD blocks defi...
<p>See legend at the bottom of the figure for explanation of symbols. DNA numbers refer to Tables S1...
Crohn�s disease is a chronic, relapsing inflammatory bowel disease; it affects the mucosa and deep...
<p>Mutation carriers and non-carriers are indicated with red and green squares, respectively. Diagno...
<p>NCI-318 (A) and MSK-41 (B) pedigrees are shown. Red symbols indicate affected individuals. The pi...
<p>Pedigrees of the Families a) 16, b) 83 and c) 42. Solid boxes and circles represent affected fami...
<p>Regional plots of the SNP p-values obtained in the discovery GWAS for a ±250 kb window around eac...
Background: A large family of Moroccan immigrants was investigated. In this family the father develo...
The high frequency of familial Crohn's disease (CD) suggests a genetic predisposition. The most rece...
The common disease-common variant hypothesis is insufficient to explain the complexities of Crohn’s ...
<p>The pedigree comprised healthy parents (father is indicated as ‘1’ and mother as ‘2’), a healthy ...
Crohn’s disease is a complex genetic trait characterized by chronic relapsing intestinal inflammatio...
<p>Individuals for which DNA samples could be collected are represented in blue when unaffected and ...
<p>Putative risk haplotypes (shown in red and designated with a star) are shown for two families whe...
<p>Affected individuals are indicated with filled symbols and unaffected individuals are indicated w...
<p>(<b>A</b>) Map of the 5q31 risk locus containing –log(P) values of SNPs (CD SNPs), LD blocks defi...
<p>See legend at the bottom of the figure for explanation of symbols. DNA numbers refer to Tables S1...
Crohn�s disease is a chronic, relapsing inflammatory bowel disease; it affects the mucosa and deep...
<p>Mutation carriers and non-carriers are indicated with red and green squares, respectively. Diagno...
<p>NCI-318 (A) and MSK-41 (B) pedigrees are shown. Red symbols indicate affected individuals. The pi...
<p>Pedigrees of the Families a) 16, b) 83 and c) 42. Solid boxes and circles represent affected fami...
<p>Regional plots of the SNP p-values obtained in the discovery GWAS for a ±250 kb window around eac...
Background: A large family of Moroccan immigrants was investigated. In this family the father develo...
The high frequency of familial Crohn's disease (CD) suggests a genetic predisposition. The most rece...
The common disease-common variant hypothesis is insufficient to explain the complexities of Crohn’s ...