Domain architecture of the three <i>A</i>. <i>baumannii</i> ATCC 19606^T phospholipase D candidates.

<p>PLD1 and PLD2 each possess PLDc_2 Pfam domains (PF13091). Each domain harbors the conserved motif characteristic for the active center of type D phospholipases. PLD3 has only a single PLD domain encompassing a HKD-like motif (HxKx₄Dx₆GS/GGxN) where the functionally relevant aspartate is replaced by a tyrosine. A second canonical HKD motif is present in the N-terminal half of the protein and outside the context of a PLDc_2 domain. While both, PLD2 and PLD3, appear membrane bound proteins, PLD1 lacks a transmembrane domain (TM).