FL-MMP-2 and NTT-MMP-2 are found within discrete tubular epithelial cellular compartments.

<p>Images of DGF biopsies were acquired using Nomarksi optics and processed with pseudocolor to enhance contrast as detailed in Materials and Methods. Panel A: Immunohistochemical staining for FL-MMP-2 is confined to the cytoplasmic compartment (N, nucleus). Panel B: Immunohistochemical staining for NTT-MMP-2 is concentrated at the basolateral surfaces of the proximal tubular epithelial cells adjacent to the tubular basement membrane. The insert demonstrates NTT-MMP-2 staining within extended filamentous structures contained within basolateral infoldings characteristic of mitochondria. (Final magnification Panels A, B: X600, insert X1200).