Nucleophilic Iododifluoromethylation of Aldehydes Using Bromine/Iodine Exchange
- Vitalij V. Levin (1345599)
- Vladimir O. Smirnov (1528486)
- Marina I. Struchkova (1345590)
- Alexander D. Dilman (1345596)
Publication date
September 2015
DOIAbstract
A method for the iododifluoromethylation of aromatic aldehydes using (bromodifluoromethyl)trimethylsilane (Me<sub>3</sub>SiCF<sub>2</sub>Br) is described. The selective formation of the CF<sub>2</sub>I group is based on using sodium iodide, with the sodium serving as a scavenger of bromide and iodide serving as a nucleophile with respect to difluorocarbene. The primary CF<sub>2</sub>I-addition products can undergo HI-elimination or iodine/zinc exchange followed by allylation in a one-pot manner
Extracted data
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