Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe hereditary cardiac ion-channel disease, which is caused by mutations in ryanodine receptor 2 (RYR2) or calsequestrin 2 (CASQ2). After β-adrenergic stimulation, these mutations lead to unwanted Ca2+ release from the sarcoplasmic reticulum (SR), which can cause life threatening arrhythmias, and sudden cardiac death. However, the underlying mechanisms how exactly point mutations in RYR2 induce arrhythmias have not been completely understood. Aim of this project was to establish in vitro disease models using human induced pluripotent stem cells (hiPSCs) as unlimited source for cardiomyocytes (CMs) and to study the molecular mechanism of CPVT. In this study, hiPSCs were g...
Since the discovery of the DNA double helix, major advances in biology have been; the development of...
Mutations in the p97 (VCP, valosin containing protein) gene cause a late-onset form of autosomal dom...
Peritoneal metastasis is relatively resistant to systemic chemotherapy and has a poor prognosis. The...
Microcephaly describes a reduced brain size in patients that manifests in an evidently reduced head ...
By utilizing x-ray crystallography and electron microscopy (EM), this thesis describes the structure...
Der Herzmuskel muss sich einer dynamischen und sich mechanisch verändernden Umgebung anpassen. Die M...
Cell based in vitro experiments consist an essential tool in many research fields as they offer a fa...
Head and neck squamous cell carcinoma (HNSCC) is one of most common human malignancies worldwide wit...
Extracellular matrices (ECMs) in soft tissues are highly hydrated structures mainly composed of glyc...
Tonicity-Responsive Enhancer Binding Protein (TonEBP), also known as nuclear factor of activated T c...
Cyclooxygenase 2 is a key enzyme in the production of prostaglandins. The widespread application of ...
Excitation contraction coupling (ECC) is the process whereby an action potential spreading throughou...
The highly conserved mitogen activated protein kinase (MAPK) high-osmolarity glycerol (HOG) pathway ...
Cartilage is essential to joint development and function. However, there is a variety of cartilage d...
Age-related macular degeneration (AMD) is a frequent disorder of the central retina. So far, the pat...
Since the discovery of the DNA double helix, major advances in biology have been; the development of...
Mutations in the p97 (VCP, valosin containing protein) gene cause a late-onset form of autosomal dom...
Peritoneal metastasis is relatively resistant to systemic chemotherapy and has a poor prognosis. The...
Microcephaly describes a reduced brain size in patients that manifests in an evidently reduced head ...
By utilizing x-ray crystallography and electron microscopy (EM), this thesis describes the structure...
Der Herzmuskel muss sich einer dynamischen und sich mechanisch verändernden Umgebung anpassen. Die M...
Cell based in vitro experiments consist an essential tool in many research fields as they offer a fa...
Head and neck squamous cell carcinoma (HNSCC) is one of most common human malignancies worldwide wit...
Extracellular matrices (ECMs) in soft tissues are highly hydrated structures mainly composed of glyc...
Tonicity-Responsive Enhancer Binding Protein (TonEBP), also known as nuclear factor of activated T c...
Cyclooxygenase 2 is a key enzyme in the production of prostaglandins. The widespread application of ...
Excitation contraction coupling (ECC) is the process whereby an action potential spreading throughou...
The highly conserved mitogen activated protein kinase (MAPK) high-osmolarity glycerol (HOG) pathway ...
Cartilage is essential to joint development and function. However, there is a variety of cartilage d...
Age-related macular degeneration (AMD) is a frequent disorder of the central retina. So far, the pat...
Since the discovery of the DNA double helix, major advances in biology have been; the development of...
Mutations in the p97 (VCP, valosin containing protein) gene cause a late-onset form of autosomal dom...
Peritoneal metastasis is relatively resistant to systemic chemotherapy and has a poor prognosis. The...