Cx3cr1^-/- has no effect on weight, body composition, or energy homeostasis.

<p>(a) Weight on chow diet (at 8 weeks) and weight gain over 24 weeks of feeding with 45% fat diet is identical between groups (n = 11 WT, 10 Cx3cr1^-/-). The high-fat fed mice do show increased weight compared to age-matched chow-fed mice of each genotype (n = 6 WT, 8 Cx3cr1^-/-) p = 0.02 at 2 weeks, 0.006 at 13 weeks, and <0.001 at 18 and 24 weeks HFD (b) At 4, 12, and 18 weeks body fat percentage via NMR was no different between groups (n = 15 WT/13 Cx3cr1^-/- at 4 weeks, 28 WT/30 Cx3cr1^-/- at 12 weeks, and 19 WT/14 Cx3cr1^-/- at 18 weeks HFD). Mice were identical in CLAMS metabolic measures of c) diet, d) VO2, e) respiratory quotient (RER) and f) activity (n = 10 WT, 8 Cx3cr1^-/-) at 18 weeks HFD. Data are mean +/- SD. *p<0.05 **p<0.01 ***p<0.001 between groups.