Transcription factors controlling the expression of genes in clusters.

<p>¹Transcription Factor</p><p>²The P-value denotes the significance of overlap with genes in the cluster (i.e., transcription factor expected to be activated or inhibited given the observed genes in the cluster) as calculated by Ingenuity Pathway Analysis.</p><p>³Type of molecule: TR = Transcription Regulator; LDNR = Ligand-dependent nuclear receptor</p><p>*Included as DEG in cluster 4.</p><p>Reported are the 31 transcription factors with a p-value of overlap <0.0005. The p-value of overlap indicates the statistical significance of genes in the dataset that are downstream of the transcription factor. Complete results are available in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137644#pone.0137644.s025" target="_blank">S10 File</a>.