Depiction of the original targets of some of the drugs used against the Ebola virus polymerase.

<p>The target polymerase and the name of the drug are indicated below each structure. The three structural subdomains are colored as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0139001#pone.0139001.g001" target="_blank">Fig 1</a>. (A) Ebola virus polymerase predicted model (B) herpes virus DNA-dependent DNA polymerase (edited from PDB: 2GV9) (C) human immunodeficiency virus-1 reverse transcriptase (edited from PDB: 4G1Q) (D) influenza A virus RNA-dependent RNA polymerase (edited from PDB: 4WSB).