<p>Close-up images of the substrate binding sites for the ten enzymes in our benchmark with known specificity altering mutations are shown in stick representation. The PDB IDs of the wild-type (green) and mutant (orange) structures are displayed in each panel.</p
<p>The structure of GCK in the closed form (PDB code:1v4s) is shown as cyan ribbons. A) p.His137Asp....
<p>The set of PDB structures used to compare the community structure of stable and unstable mutants ...
The specific sequence of amino acids in a polypeptide chain dictates the three-dimensional structure...
<p><b>(A) Wild-type enzyme; (B) A269K/S187D mutant; (C) S187D/N188T mutant; D) A269K/S187D/N188T mut...
<p>Gene and protein identifiers are shown together with the PDB code of structural evidence of inter...
<p>(A) Wild type enzyme; (B) A220D and E228S mutants. A220 and E228 are both located on the entrance...
<p>Wild-type (grey) and 6B (pink) crystal structures were overlapped. Side chain of active site resi...
<p>The structure of GCK in the closed form (PDB code: 1v4s) is represented by cyan ribbons. A) Mutat...
Recent developments in molecular biology offer new approaches for improving our understanding of enz...
<p>The top panel displays a close-up of the active site with 3’SL docked (yellow, sticks). The 16 mu...
<p>(a) Crystal structure (PDB id: 3W4U) depicting a D100Y mutation (on Hbb) at an interface residue ...
<p>(<b>A</b>) Overlay of the wild type (PDB ID code 1IH7; navy blue) and Pol<sup>D714A</sup> apoenzy...
<p><b>a)</b> Changes in the geometry of the protein tertiary structures. Wild type, red; CYP2A6*15, ...
<p>Shown in dark green is one monomer from an N1 neuraminidase crystal structure (<a href="http://ww...
<div><p>The ability of an enzyme to select and act upon a specific class of compounds with unerring ...
<p>The structure of GCK in the closed form (PDB code:1v4s) is shown as cyan ribbons. A) p.His137Asp....
<p>The set of PDB structures used to compare the community structure of stable and unstable mutants ...
The specific sequence of amino acids in a polypeptide chain dictates the three-dimensional structure...
<p><b>(A) Wild-type enzyme; (B) A269K/S187D mutant; (C) S187D/N188T mutant; D) A269K/S187D/N188T mut...
<p>Gene and protein identifiers are shown together with the PDB code of structural evidence of inter...
<p>(A) Wild type enzyme; (B) A220D and E228S mutants. A220 and E228 are both located on the entrance...
<p>Wild-type (grey) and 6B (pink) crystal structures were overlapped. Side chain of active site resi...
<p>The structure of GCK in the closed form (PDB code: 1v4s) is represented by cyan ribbons. A) Mutat...
Recent developments in molecular biology offer new approaches for improving our understanding of enz...
<p>The top panel displays a close-up of the active site with 3’SL docked (yellow, sticks). The 16 mu...
<p>(a) Crystal structure (PDB id: 3W4U) depicting a D100Y mutation (on Hbb) at an interface residue ...
<p>(<b>A</b>) Overlay of the wild type (PDB ID code 1IH7; navy blue) and Pol<sup>D714A</sup> apoenzy...
<p><b>a)</b> Changes in the geometry of the protein tertiary structures. Wild type, red; CYP2A6*15, ...
<p>Shown in dark green is one monomer from an N1 neuraminidase crystal structure (<a href="http://ww...
<div><p>The ability of an enzyme to select and act upon a specific class of compounds with unerring ...
<p>The structure of GCK in the closed form (PDB code:1v4s) is shown as cyan ribbons. A) p.His137Asp....
<p>The set of PDB structures used to compare the community structure of stable and unstable mutants ...
The specific sequence of amino acids in a polypeptide chain dictates the three-dimensional structure...
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