Slice with the largest tumour cross-section of a representative primary tumour.

<p><b>(a)</b> ROI (red) contoured on the most enhanced frame of the DCE series, <b>(b)</b> ROI (blue) contoured on b = 1000 image of the DWI series, <b>(c)</b> IAUG60 map, <b>(d)</b> ADC map, with the two ROIs overlapped, and <b>(e)</b> cluster analysis map pre and post-induction chemotherapy (IC), in the simplest case of k = 2. The red ROI also encompasses the region where cluster analysis was performed; the blue ROIs represent the area of restricted diffusion independently contoured on DWI data, almost coincident with Cluster 1, which is characterized by both low ADC and high IAUGC60 values.