ADAM12 is associated with mesenchymal-like phenotype of Basal-B cell lines.

<p>Based on gene expression data of breast cell lines (n = 51) from Neve et al.[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0139179#pone.0139179.ref036" target="_blank">36</a>] and Kao et al.[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0139179#pone.0139179.ref037" target="_blank">37</a>], statistical analyses identified 635 overexpressed genes in Basal-B cell lines compared with Luminal and Basal-A cells (Detailed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0139179#pone.0139179.s008" target="_blank">S2 Table</a>). (A) Text mining analysis of the 100 most statistically significant upregulated genes in Basal-B cell lines using CoPub tool. Nodes represent genes and edges represent co-citation in abstract. Black lines indicate ADAM12 connections. (B) Spearman correlation analyses of steady-state ADAM12L, ADAM12S, vimentin, E-cadherin and N-cadherin mRNA levels (Top). Comparative distribution of mRNA levels of ADAM12, vimentin, E-cadherin, N-cadherin and TGF-β between Lum/Basal-A and Basal B cell lines (Bottom). (***,p<0.001; **,p<0.01; *, p<0.005).